A quick tip is to cache your .pdb files onto your local machine when debugging .NET. This means that each time you debug the source then you don’t suffer the performance hit of downloading all the files again.
In Visual Studio go to Tools->Options and navigate to Symbols.
Make sure you deselect the option to search the above locations and cache the files. In the example I have created a folder on my c:\ drive called RSCC where the files are saved.